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Xinyu Liu Prof. Samuel H. Gellman 《Chembiochem : a European journal of chemical biology》2021,22(18):2772-2776
Assemblies of racemic β-sheet-forming peptides have attracted attention for biomedical applications because racemic forms of peptides can self-associate more avidly than do single enantiomers. In 1953, Pauling and Corey proposed “rippled β-sheet” modes of H-bond-mediated interstrand assembly for alternating L- and D-peptide strands; this structural hypothesis was complementary to their proposal of “pleated β-sheet” assembly for L-peptides. Although no high-resolution structure has been reported for a rippled β-sheet, there is strong evidence for the occurrence of rippled β-sheets in some racemic peptide assemblies. Here we compare propensities of peptide diastereomers in aqueous solution to form a minimum increment of β-sheet in which two antiparallel strands associate. β-Hairpin folding is observed for homochiral peptides with aligned nonpolar side chains, but no β-hairpin population can be detected for diastereomers in which one strand contains L residues and the other contains D residues. These observations suggest that rippled β-sheet assemblies are stabilized by interactions between β-sheet layers rather than interactions within these layers. 相似文献
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介绍了折褶滤芯的类型和结构参数,结合前人的经验总结出了一套适用于计算折褶滤芯压力损失的理论公式.以125L过滤器为依托,通过验证计算找出了两种折褶滤芯的最优参数,并利用FLUENT技术模拟出在给定压力下折褶滤芯内外部的速度和压力的变化,进一步验证了理论公式的正确性. 相似文献
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有源电力滤波器(Active Power Filter,简称APF)是一种动态抑制谐波和补偿无功功率的新型电力电子装置,其输出的电流中含有丰富的谐波成份.APF主电路中的功率器件不可避免地存在死区时间,这将极大地影响APF输出的谐波电流,从而对APF的补偿性能产生消极影响.以三相电压型PWM变流器为研究对象,简要分析并联型APF的工作原理.在此基础上,详细研究了死区时间的产生机理和效应,并通过数学推理定量分析了死区时间的存在对补偿性能的影响,并通过试验证明了数学推理的正确性,最后提出了死区补偿的措施. 相似文献
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基于随机多层纤维过滤介质算法建立褶式滤芯三维拟态化结构模型,对褶式滤芯内部气-固两相流动进行数值模拟,计算不同运行参数及结构参数下滤芯的压力损失及过滤效率,并与文献计算值进行比较. 结果表明,压力损失随过滤风速增大呈线性增加;随褶尖角增大,压力损失呈先减小后增加,压力损失计算值与文献计算值吻合较好. 褶尖角和过滤风速一定时,过滤效率随粒径增加先减小后增大,在给出的颗粒直径范围内存在最易穿透颗粒直径(MPPS). 不同过滤风速下,当颗粒粒径小于0.5 mm时,扩散作用使过滤效率随过滤风速增加而减小;大于0.5 mm时,惯性作用使其随过滤风速增加而增加;MPPS随风速增加而减小;本计算值与文献计算值趋势一致. 不同褶尖角下,当颗粒粒径小于1 mm时,扩散作用使过滤效率随褶尖角增大而减小;大于1 mm时,惯性作用使其随褶尖角增大而增加. 相似文献
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